healthy person
Conditions
Interventions
Fasting (fasting for 36 to 48 hours) in a facility supervised by a physician. During the fasting period, blood glucose levels will be constantly monitored using a continuous glucose meter. During the
s physician as appropriate). The amount of fluid required for each patient should be calculated, and the patient should be encouraged to drink as the minimum daily fluid intake (fluid requirement (ml/
Sponsors
Juntendo University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. be 20 years of age or older at the time of consent 2. who are able to visit the Department of Urology, Juntendo University Hospital, Juntendo University School of Medicine, or who are able to visit the hospital 3. who have received a full explanation of their participation in this study, and who have given their consent of their own free will based on a thorough understanding of the study
Exclusion criteria
Exclusion criteria: Those who could not obtain consent. Those who are under 20 years of age at the time of obtaining consent. Systemic infection, acute or chronic viral hepatitis, diabetes mellitus with poor glycemic control, serious renal or hepatic dysfunction, serious cardiovascular or cerebrovascular disease within 6 months, serious gastrointestinal disease or gastric surgery within 12 months, active malignancy within 5 years, current or planned pregnancy, lactation. Persons deemed inappropriate as research subjects by the principal investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood samples and body composition will be collected and examined up to 3 times/year before fasting, immediately after fasting, and 1-4 weeks after fasting. X chromosome copy number Y chromosome copy number Mitochondria number Leukocyte telomere length, epigenetic clock based on epigenetics information, gene expression in blood cells (RT-qPCR, RNA-Seq, non-coding RNA, single cell RNA-Seq), expression of aging-related proteins expression levels (Rubicon, etc.), mosaic chromosomal alteration (mCA) and genotypes using SNP arrays | — |
Secondary
| Measure | Time frame |
|---|---|
| Basic patient information: age, gender, medical history, height, weight Vital information: body temperature, blood pressure, heart rate, heart rate variability, respiratory rate, oxygen saturation Disease information: name of disease Laboratory results: urinalysis, blood count, coagulation/fibrinolysis, serum, blood glucose, biochemistry, free testosterone, thyroid hormone, (for cancer patients) tumor markers, QOL Treatment: information on surgical treatment, chemotherapy, endocrine therapy, radiation therapy, exercise therapy, diet, supportive care, behavioral therapy, information on medications (including herbal medicines and supplements), prognosis | — |
Countries
Japan
Contacts
Public ContactYoshihiro Ikehata
Juntendo University, Graduate School of Medicine Department of Urology
Outcome results
None listed