Autosomal dominant polycystic kidney
Conditions
Interventions
Change diet to plant-focused diet supported by KetoCitra.
Continue with the same dietary habits.
Sponsors
Department of Urology, Juntendo University Graduate School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Male or female, 18 years of age or older (2) Have a confirmed diagnosis of ADPKD based on ADPKD guidelines (3) Estimated glomerular filtration rate (eGFR) >30 mL/min/1.73 m2 at screening (according to [CKD-EPI] formula) (4) Female participants are not pregnant or lactating or planning to become pregnant or lactating during the study period (5) Able to read, understand, and respond to the survey form (6) Have no problems with the web environment and are able to take online classes. Also, able to complete the form online (7) Have voluntary written consent to participate in the study
Exclusion criteria
Exclusion criteria: (1) poorly controlled diabetes mellitus with HbA1C > 8.0 (2) Uncontrolled dyslipidemia with LDL cholesterol > 4 mmol/L or triglycerides > 3 mmol/L (3) Uncontrolled hypertension (SBP > 160 and/or BP > 100 mm Hg on 3 occasions) (5) Hyperkalemia (>5.5 mmol/l). (6) Significant disease such as malignancy within the past 5 years, autoimmune disease under immunosuppressive treatment (8) On any medication (SGLT2 inhibitor) or investigational drug that may affect the safety of the ketogenic diet (since bardoxolone methyl for ADPKD is under investigation in Japan). (12) Food sensitivities or allergies incompatible with the nutritional program (13) Subject is already compliant with a ketogenic diet or fasting (14) Current or past history of eating disorders or eating behaviors (16) Ulcerative colitis, irritable bowel syndrome, Crohn's disease, or gallbladder disease (17) BMI less than 18
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Health status assessment (baseline and 3, 6, 9, and 12 months) Height, weight, BMI, abdominal circumference, blood pressure Blood samples (blood count, biochemistry; BUN, Cre, AST, ALT, LDH, ALP, T-Bil, D-Bil, fasting blood sugar, total-LDL-HDL-cholesterol, TG, HbA1c, CRP, adiponectin, leptin, ghrelin) Urine (specific gravity, PH, protein, ketone bodies, white blood cells, red blood cells, glucose, creatinine, Na, Pi) Height-adjusted total kidney volume (hTKV) from MRI or other imaging studies (at baseline and 12 months only, not exceeding the range of actual clinical kidney volume measurements) (Not to exceed the range of actual clinical renal volume measurements at baseline and 12 months only) Home measurements of blood ketone levels, blood glucose levels, and urinary Ph: daily for 1-12 weeks, weekly thereafter. Only these three items will be collected at home. Only these three items will be collected at home, and the others at the hospital. | — |
Countries
Japan
Contacts
Public ContactHaruna Kawano
Juntendo University Graduate School of Medicine Department of Urology
Outcome results
None listed