A Randomized Crossover Trial Comparing Lower Limb Negative Pressure Loading with Gravitational Loading in Healthy Subjects

A Randomized Crossover Trial Comparing Lower Limb Negative Pressure Loading with Gravitational Loading in Healthy Subjects - Efficacy Trial of a Lower Limb Negative Pressure Loading Device

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000052897

Enrollment

Registered

2023-11-24

Start date

2023-11-24

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy Subjects

Interventions

Sitting Test: Transitioning from a supine position to a sitting position (10 minutes rest, 5 minutes sitting) Standing Test: Transitioning from a supine position to a passive upright position using a

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Healthy individuals with blood pressure within the normal range at rest

Exclusion criteria

Exclusion criteria: (1) Individuals who have experienced symptoms such as dizziness or nausea associated with orthostatic hypotension in the past 6 months. (2) Individuals with arrhythmia. (3) Individuals taking cardiovascular drugs that affect blood pressure, heart rate, or autonomic nervous activity. (4) Women who are pregnant, may be pregnant, or are breastfeeding. (5) Others whom the person in charge of this trial deems inappropriate.

Design outcomes

Primary

Measure	Time frame
Change in Stroke Volume	—

Secondary

Measure	Time frame
Heart Rate, Systolic/Diastolic Blood Pressure, Total Peripheral Resistance, Parasympathetic Nervous Activity, Lower Limb Muscle Blood Flow, Lower Limb Skin Blood Flow, Earlobe Blood Flow	—

Countries

Japan

Contacts

Public ContactTakumi Hirabayashi

Kobe University Hospital Division of Rehabilitation Medicine

hirabayashi@phoenix.kobe-u.ac.jp078-382-6494

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026