Thyroid disease requiring total thyroidectomy
Conditions
Interventions
None listed
Sponsors
Niigata University Faculty of Medicine Department of Otolaryngology Head and Neck Surgery Takeshi Takahashi
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Clinical studies are included if they meet the following criteria: (a) studies that included patients with thyroid disease (benign or malig- nant) who underwent total thyroidectomy; (b) studies that compared postoperative parathyroid function between Near-infrared imaging techniques and conventional surgery; and (c) studies that evaluated postoperative calcium and/or parathyroid hormone levels and the rate of hypocalcemia and/or hypoparathyroidism.
Exclusion criteria
Exclusion criteria: We exclude clinical studies that meet the following exclusion criteria: (a) those that included patients who underwent hemithyroidectomy, lobectomy, or partial thyroidectomy with or without central compartment neck dissection; (b) those in which other optical techniques (such as indocyanine green and methylene blue) were used for parathyroid gland protection during surgical procedure; (c) those that included patients with preoperative parathyroid gland disease and/or abnormal parathyroid function; and (d) reviews, meta-analyses, case reports, and animal experiments or basic research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of patients who developed hypocalcemia immediately after surgery and after long-term postoperative course | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of parathyroid glands discovered during surgery, number of parathyroid autotransplantation, number of parathyroid glands accidentally removed, number of patients with hypoparathyroidism immediately after surgery and after long-term follow-up. A meta-analysis was performed using the incidence of temporary/permanent-hypocalcemia/parathyroidism was compared between the groups using nearinfrared autofluorescense techniques and the naked-eye to identify parathyroid glands. Meta-regression analyses were performed for each outcome to identify the moderators that influenced the pooled estimates of the meta-analyses. These moderators were: 1) disease type (malignant or benign), assessed by the rate of malignant disease; and 2) surgeon skill, assessed by the incidence of temporary hypocalcemia relying on the naked-eye. | — |
Countries
Japan
Contacts
Public ContactTakeshi Takahashi
Niigata University Faculty of Medicine Department of Otolaryngology Head and Neck Surgery
Outcome results
None listed