Glioma, Meningioma
Conditions
Interventions
None listed
Sponsors
Hokkaido university
Southern TOHOKU Proton therapy center, University of Tsukuba Hospital, National Cancer Center Hospital East, Aizawa Hospital, Nagoya city university west medical center, Fukui prefectural hospital, Hyogo ion beam medical center, Medipolis Proton Therapy and Research Center, Tsuyama Chuo Hospital, Sapporo Teishinkai hospital, University hospital Kyoto prefectural university of medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Among patients with glioma and meningioma who were registered in the proton beam registry database, radiation therapy was started between May 1, 2016 and April 30, 2021, and treatment plan data could be submitted in DICOM format. A person who is capable of outputting information and who has not received a refusal to participate in this research from a research subject or a person who is considered to be able to represent the wishes and interests of the research subject.
Exclusion criteria
Exclusion criteria: 1. Persons of nationality other than Japan 2. Persons who underwent hyperfractionated irradiation (irradiation twice a day) 3. Persons who received proton beam therapy as private practice 4. Persons who have undergone proton beam therapy to areas with a history of radiation therapy 5. Other persons deemed unsuitable as research subjects by the research director
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Model based normal tissue complication probability (NTCP) (alopecia, hearing inmairment, tinnitus, cognitive disorder, blindness, cataract, brain necrosis, endocrine dysfunction, second malignancy) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Search for indicators that indicate the validity of plan comparison in planning studies 2. Search for indicators to select patients for whom proton beam therapy is desirable 3. Comparison of actual probability of adverse event occurrence and predicted NTCP (performance evaluation of NTCP model) | — |
Countries
Japan
Contacts
Public ContactKentaro Nishioka
Hokkaido university Global Center for Biomedical Science and Engineering
Outcome results
None listed