A Randomized Controlled trial to compare the efficacy of intraperitoneal instillation of Bupivacaine with Lidocaine for post-operative pain relief in patients undergoing Laparoscopic cholecystectomy

A Randomized Controlled trial to compare the efficacy of intraperitoneal instillation of Bupivacaine with Lidocaine for post-operative pain relief in patients undergoing Laparoscopic cholecystectomy - PReACh

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000052551

Enrollment

176

Registered

2023-10-20

Start date

2019-08-27

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gall stone disease

Interventions

Group A-Lidocaine instillation before gall bladder (GB) dissection Group B-Lidocaine instillation after GB dissection Group C-L-Bupivacaine instillation before GB dissection Group D-L-Bupiv

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients with symptomatic Cholelithiasis/ GB sludge (dyspepsia, pain) 2. Patients with asymptomatic gall stones disease. 3. Solitary polyps of more than 6 mm or multiple gall bladder polyps or progressively enlarging gall bladder polyp

Exclusion criteria

Exclusion criteria: 1. Conversion from Laparoscopic to open cholecystectomy 2. Patients with Jaundice 3. Intra-operative detection of concomitant pathology in other organs (Appendix, bowel, liver, stomach) 4. Duration of surgery more than 90 minutes 5. Any Patient in whom Drain was placed after Surgery 6. Allergies to L-Bupivacaine/Lidocaine

Design outcomes

Primary

Measure	Time frame
Post-operative pain as assessed by Visual analog score, heart rate, mean arterial pressure	—

Countries

Asia(except Japan)

Contacts

Public ContactAishwainee VG

Sikkim Manipal Institute of Medical Sciences Department of General Surgery, Central Referral Hospital

aishwainee@gmail.com8867710850

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026