Study on the effect of oligosaccharides on bile acid metabolism in the human gut microbiota

Study on the impact of difructose anhydride III (DFA III) on bile acid metabolism in the human fecal microbiota - Study on bile acid metabolism of difructose anhydride III (DFA III)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000052468

Enrollment

Registered

2024-08-01

Start date

2023-10-11

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy individuals(adults)

Interventions

DFA III will be administered at a dosage of 4.0 grams twice a day, in the morning and evening, for a total of 10 days (8.0 grams per day).

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Participants aged 20 and above of both genders. 2. Individuals who have received adequate explanation about the purpose and content of the study, and have provided written consent to participate.

Exclusion criteria

Exclusion criteria: Not applicable

Design outcomes

Primary

Measure	Time frame
Evaluation of the ratio of secondary bile acids to primary bile acids in in vitro inoculation of fecal gut microbiota, both before and after 10 days of DFA III intake, at 0-24 hours of incubation, alongside primary bile salts.	—

Secondary

Measure	Time frame
Assessment of the quantity of individual bile acids in stool, as well as the gene expression of secondary bile acid metabolism enzymes, before and after 10 days of DFA III consumption.	—

Countries

Japan

Contacts

Public ContactKyu-Ho Han

Obihiro University of Agriculture and Veterinary Medicine Department of Life and Food Sciences

kyuho@obihiro.ac.jp0155495561

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026