Patients with peritoneal dialysis
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1) Outpatients with peritoneal dialysis 2) Patients who meet the criteria of sarcopenia(defined by walking speed, grip strength, and skeletal mass index). 3) Patients who have pains of locomotor. 4) Patients from whom we can obtain informed consent.
Exclusion criteria
Exclusion criteria: 1)Patients who are contraindicated for exercise training. Concrete criteria are as follows: patients with uncontrolled persistent hypertension (systolic blood pressure >= 180 mmHg or diastolic pressure >= 110 mmHg); severe anemia (Hb < 7 g/dL); active proliferative diabetic retinopathy; prior symptomatic coronary artery or cerebrovascular diseases within the previous 3 months; uncontrolled heart failure (NYHA >= III); symptomatic or lethal arrhythmia; severe valvular diseases; and walking difficulty due to orthopedic, cerebrovascular and peripheral artery diseases. 2) Unstable PD patients. Concrete criteria are as follows: patients who undergo PD less than 3 months and those with uncontrolled uremia (BUN > 100 mg/dL, K > 6.0 mEq/L and HCO3 < 18 mmoL/L). 3) Patients deemed inadequate for monitoring during study period, as determined by investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Six-minute walk test as an index of aerobic capacity in 12 weeks after assignment. | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluation factors of sarcopenia (walking speed, grip strength, and skeletal mass index), ABI/PWV, body composition index, CKD-related parameters (serum Na/K/Cl, Ca/P/PTH intact, UA, TC/HDL/TG, Hb, carnitine), residual kidney function, Numerical Rate Scale of locomotor, evaluated 12 weeks after assignment. | — |
Countries
Japan
Contacts
Japanese Red Cross Medical Center DIvision of Nephorology