Comparative study of therapeutic drugs for hyperkalemia in hemodialysis patients

Comparison of the effects of sodium zirconium cyclosilicate and cation exchange resin on electrolytes, nutritional status, and metabolic acidosis in hemodialysis patients with hyperkalemia - Comparison of the effects of sodium zirconium cyclosilicate and cation exchange resin on electrolytes, nutritional status, and metabolic acidosis in hemodialysis patients with hyperkalemia

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000052437

Enrollment

Registered

2023-10-08

Start date

2023-10-09

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

End stage kidney disease hyperkalemia

Interventions

Switched from cation exchange resin to sodium zirconium cyclosilicate (5g once on non-dialysis days) for 12 weeks

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Maintenance hemodialysis patients receiving hemodialysis three times a week Patients undergoing treatment for hyperkalemia with resin Patients who have obtained written informed consent of their own free will to participate in this study

Exclusion criteria

Exclusion criteria: Patients allergic to sodium zirconium cyclosilicate hydrate Patients who are breastfeeding or pregnant

Design outcomes

Primary

Measure	Time frame
Changes in serum potassium levels before and after switching from cation exchange resin to sodium zirconium cyclosilicate hydrate	—

Secondary

Measure	Time frame
Comparison of electrolyte values before and after switching from cation exchange resin to zirconium sodium cyclosilicate hydrate Comparison of bicarbonate concentration before and after switching from cation exchange resin to zirconium sodium cyclosilicate hydrate Comparison of Geriatric Nutritional Risk Index (GNRI) values before and after switching from cation exchange resin to zirconium sodium cyclosilicate hydrate	—

Measure

Time frame

Comparison of electrolyte values before and after switching from cation exchange resin to zirconium sodium cyclosilicate hydrate Comparison of bicarbonate concentration before and after switching from cation exchange resin to zirconium sodium cyclosilicate hydrate Comparison of Geriatric Nutritional Risk Index (GNRI) values before and after switching from cation exchange resin to zirconium sodium cyclosilicate hydrate

—

Countries

Japan

Contacts

Public ContactNaofumi Ikeda

Saitama Sekishinkai Hospital Department of Nephrology

naofumi-ikeda@saitama-sekishinkai.org04-2953-6611

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026