Can measurement of heart rate variability be a quantitative assessment of pain in cognitively impaired pain patients?

Can measurement of heart rate variability be a quantitative assessment of pain in cognitively impaired pain patients? - Can measurement of heart rate variability be a quantitative assessment of pain in cognitively impaired pain patients?

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000052413

Enrollment

Registered

2025-03-15

Start date

2023-10-05

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 20 to 100 years old

Exclusion criteria

Exclusion criteria: Diabetes mellitus Depression Persons taking antidepressants, beta-blockers, Ca antagonists, antiepileptic drugs, etc. Hypothyroidism, hyperthyroidism

Design outcomes

Primary

Measure	Time frame
Inpatients in the normal cognitive function group and the cognitively impaired group will be asked to verbally answer the Numerical Rating Scale daily. A heart rate variability measurement device will be placed on the bilateral forearms. Resting sitting position will be performed for 10 minutes, and the ECG will be recorded for the latter 5 minutes. The detected RR waveforms will be analyzed in the time domain and frequency domain. In the time domain analysis, RR intervals , SDNN , NN50 , and pNN50 are used as parameters. In the frequency analysis, the spectral power densities of the different component frequencies of HR are obtained by Fast Fourier Transform. The power spectrum is divided into three frequency bands: VLF 0.001-0.04 Hz, LF 0.040-0.15 Hz, and HF 0.15-0.4 Hz. low frequency , high frequency, and LF/HF ratio are calculated from software. These will be measured for 30 days to see if HRV correlates with pain status.	—

Measure

Time frame

Inpatients in the normal cognitive function group and the cognitively impaired group will be asked to verbally answer the Numerical Rating Scale daily. A heart rate variability measurement device will be placed on the bilateral forearms. Resting sitting position will be performed for 10 minutes, and the ECG will be recorded for the latter 5 minutes. The detected RR waveforms will be analyzed in the time domain and frequency domain. In the time domain analysis, RR intervals , SDNN , NN50 , and pNN50 are used as parameters. In the frequency analysis, the spectral power densities of the different component frequencies of HR are obtained by Fast Fourier Transform. The power spectrum is divided into three frequency bands: VLF 0.001-0.04 Hz, LF 0.040-0.15 Hz, and HF 0.15-0.4 Hz. low frequency , high frequency, and LF/HF ratio are calculated from software. These will be measured for 30 days to see if HRV correlates with pain status.

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Countries

Japan

Contacts

Public ContactRYOTA OSUMI

Narahigashi Hospital Department of Rehabilitation

crazy_monkeys_no11@yahoo.co.jp0743615543

Outcome results