Upper gastrointestinal cancer
Conditions
Interventions
None listed
Sponsors
Nagoya University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Cases diagnosed with upper gastrointestinal cancer and scheduled for initial chemotherapy with HEC regimen containing Cisplatin 2. Cases diagnosed with upper gastrointestinal cancer and scheduled for initial chemotherapy with MEC regimen containing Oxaliplatin 3. Diagnosed with upper gastrointestinal cancer, chemotherapy containing HEC containing Cisplatin or MEC containing Oxaliplatin was performed, antiemetic therapy containing an NK1 receptor antagonist antiemetic other than fosnetupitant was performed, and in which vomiting cannot be controlled 4. Cases in which the physician has determined that evaluation of nausea and vomiting associated with chemotherapy is possible 5. Cases aged 20 years or older at the time of obtaining consent 6. Cases where triple-drug combination therapy (Fosnetupitant, Palonosetron, Dexamethasone) is planned
Exclusion criteria
Exclusion criteria: 1. Cases in which emetic events are observed due to factors other than cancer chemotherapy (e.g., emetic events due to passage obstruction due to the underlying disease, emetic events due to brain metastases) 2. Cases receiving continuous systemic administration of steroids exceeding 10 mg/day of prednisone equivalent. 3. Cases in which the attending physician determines that enrollment in this study is inappropriate 4. Cases with a history of hypersensitivity to the components of Fosnetupitant, Palonosetron, and Dexamethasone 5. Pregnant women or women who may be pregnant
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Complete suppression rate of emesis within 168 hours from the start of treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of vomiting or nausea, degree of nausea, additional antiemetic measures, adverse events (according to Common Terminology Criteria for Adverse Events) | — |
Countries
Japan
Contacts
Public ContactKoki Nakanishi
Nagoya University Graduate School of Medicine Department of Gastroenterological Surgery
Outcome results
None listed