Male adults
Conditions
Interventions
Consumption of the test foods for 4 weeks
Sponsors
CPCC Company Limited
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1. Healthy males aged 60 to 75 years. 2. Subjects who defecate every morning. 3. Subjects who can give informed consent to partake in this research, after being provided with an explanation of the protocol detail.
Exclusion criteria
Exclusion criteria: 1. Subjects who take habitually (not less than 3 times a week) in the Food for Specified Health Uses (FOSHU) or Foods with Function Claims or supplementary food or health foods or yogurts or lactic acid bacteria beverages or fiber-fortified foods, oligosaccharides which might affect the test results. 2. Subjects who have taken the following medications that may affect the study for 1 month prior to the pre-test, and those who cannot limit their use from the pre-test to the time of the 4W test. 2.1 Intestinal preparations 2.2 Antibiotics 2.3 Vitamins, including vitamin B3 3. Subjects who are in the habit of smoking, or have been in the habit of smoking within the past year. 4. Subjects with excessive alcohol intake. 5. Subjects who are participating the other clinical tests. Subjects who participated within 4-weeks prior to the current study and/or who plan to participate the other clinical tests. 6. Subjects with serious or progressive preexisting illnesses or symptoms. 7. Subjects with previous and/or current medical history of serious diseases in heart, liver, kidney and/or digestive organs. 8. Subjects having some kind of drug and/or food allergy. 9. Subjects who donated blood or component (200 mL) within the last 1 months. 10. Subjects who donated his blood (400 mL) within the last 3 months. 11. Subjects who being collected in total of his blood (1200 mL) within the last 12 months and in this research. 12. Subjects deemed unsuitable for participation in the trial by the principal investigator or sub-investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NAD+-related metabolites in feces. NAD+-related metabolites in blood. | — |
Secondary
| Measure | Time frame |
|---|---|
| Comprehensive analysis of fecal flora, total bacterial count. Fecal water content. Organic acid concentration in feces. Defecation status. Abdominal symptoms at times other than defecation. | — |
Countries
Japan
Contacts
Public ContactMakoto Ichinohe
CPCC Company Limited Clinical Planning Department
Outcome results
None listed