Prenatal exposure to intra-amniotic infection with Ureaplasma species increases the prevalence of bronchopulmonary dysplasia.

Prenatal exposure to intra-amniotic infection with Ureaplasma species increases the prevalence of bronchopulmonary dysplasia. - Prenatal exposure to intra-amniotic infection with Ureaplasma species increases the prevalence of bronchopulmonary dysplasia.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000052298

Enrollment

209

Registered

2023-09-25

Start date

2022-06-10

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intra-amniotic infection

Interventions

None listed

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Patients with singleton pregnancies (between August 2014 and April 2020) who underwent inpatient management at our department for PPROM, preterm labor, cervical insufficiency, and asymptomatic cervical shortening between 22 weeks 0 days and 33 weeks 6 days of gestation were included.

Exclusion criteria

Exclusion criteria: Exclusion criteria were as follows: delivery after 34 gestational weeks, fetal chromosomal abnormalities or multiple malformations, intrauterine fetal death, delivery at another hospital, MIAC in which Ureaplasma spp. and Mycoplasma hominis were not identified, and an unclear placental pathology or umbilical vein blood interleukin (IL)-6 concentration in patients in whom intra-amniotic inflammation or MIAC was not detected by amniocentesis or for whom amniocentesis was not indicated.

Design outcomes

Primary

Measure	Time frame
The primary study outcomes were the relationships between the prevalence of BPD and intra-amniotic infection with or without Ureaplasma spp. and intra-amniotic inflammation without MIAC after adjusting for gestational age at birth.	—

Secondary

Measure	Time frame
Secondary study outcomes were the relationships between the prevalence of adverse neonatal outcomes, and intra-amniotic infection with or without Ureaplasma spp. and intra-amniotic inflammation without MIAC after adjusting for potential confounders.	—

Countries

Japan

Contacts

Public ContactMakoto Nomiyama

National Hospital Organization, Saga National Hospital Department of Obstetrics and Gynecology

nomiyama8522@gmail.com0952307141

Outcome results