Advanced or recurrent non-small cell lung cancer harboring EGFR exon21 L858R mutation
Conditions
Interventions
None listed
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: Non-small cell lung cancer has been diagnosed by either histological diagnosis (excised specimen), biopsies or cellular diagnosis. EGFR ex21 L858R mutation positive based on tissue or plasm specimen Patients with unresectable stage III, stage IV disease according to TNM classification, Version 8, or recurrence after radical treatment by surgery or chemoradiation Performance status (PS): 0-2 Patients who received Ramucirumab + Erlotinib therapy between 1 Nov. 2020 to 31 Aug. 2023
Exclusion criteria
Exclusion criteria: Active double cancers* *Double cancers are synchronous double cancers and metachronous double cancers with a disease-free interval of <3 years, and lesions in carcinoma in situ or mucosal equivalent that are considered cured by local treatment should not be included in active double cancers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to treatment failure (TTF) | — |
Secondary
| Measure | Time frame |
|---|---|
| Overall survival (OS Progression-free survival (PFS) Progression-free survival 2 (PFS2) Time to discontinuation of any EGFR-TKI (TD-TKI) Time to failure of strategy (TFS) Objective response rate (ORR) Disease control rate (DCR) Safety | — |
Countries
Japan
Contacts
Department of Internal Medicine, Teikyo University School of Medicine Division of Medical Oncology