A retrospective observational study on the treatment and prevention of drug-related osteonecrosis of the jaw

A retrospective observational study on the treatment and prevention of drug-related osteonecrosis of the jaw - A retrospective observational study on the treatment and prevention of drug-related osteonecrosis of the jaw

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000052019

Enrollment

400

Registered

2023-08-28

Start date

2023-08-29

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

drug-related osteonecrosis of the jaw

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) MRONJ patients aged 18 years or older who visited Nagasaki University Hospital Dentistry from January 1, 2011 to April 30, 2023. 2) Non-MRONJ patients aged 18 years or older who visited Nagasaki University Hospital Dentistry from January 1, 2011 to June 30, 2023 who received high-dose ARA as a comparison subject.

Exclusion criteria

Exclusion criteria: Patients who have been out of the hospital for less than one month since the initial visit.

Design outcomes

Primary

Measure	Time frame
Clinical course of MRONJ patients Number of days from the date of the first visit to the occurrence of the event with healing as the event for MRONJ patients (healing is defined as the time when the attending physician determines that all clinical symptoms, including bone exposure, have resolved) MRONJ onset in non-MRONJ patients Number of days from the date of the first visit to the occurrence of the event, where event is defined as MRONJ onset (or relapse)	—

Measure

Time frame

Clinical course of MRONJ patients Number of days from the date of the first visit to the occurrence of the event with healing as the event for MRONJ patients (healing is defined as the time when the attending physician determines that all clinical symptoms, including bone exposure, have resolved) MRONJ onset in non-MRONJ patients Number of days from the date of the first visit to the occurrence of the event, where event is defined as MRONJ onset (or relapse)

—

Countries

Japan

Contacts

Public ContactMitsunobu Otsuru

Nagasaki university oralsurgery

ootsuru@nagasaki-u.ac.jp00958197698

Outcome results