Study on Molecular Basis of Stellate Ganglion Block for Chronic Pain

Investigation of Molecular Basis of Sympathetically Maintained Pain in Chronic Orofacial Pain - Investigation of Molecular Basis of Sympathetically Maintained Pain in Chronic Orofacial Pain

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000051995

Enrollment

Registered

2023-08-24

Start date

2023-08-24

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic primary orofacial pain, Chronic secondary orofacial pain

Interventions

Unilateral stellate ganglion block with local anesthetic (0.5-1% lidocaine hydrochloride, 4-8mL)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with primary or secondary oral-facial pain lasting more than 3 months

Exclusion criteria

Exclusion criteria: Contraindications to SGB, failures of SGB, accidents by SGB, patients with diagnosed psychiatric disorder.

Design outcomes

Primary

Measure	Time frame
Pain- and stress-related biomarkers on pre- and post-SGB in saliva (i.e. Brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), cortisol, alpha-amylase, chromogranin A).	—

Secondary

Measure	Time frame
Other pain- and stress-related biomarkers in saliva or blood (i.e. serotonin, noradrenaline, interleukin-1beta (IL-1beta), IL-6, IL-8, substance P, endorphin, dehydroepiandrosterone, noradrenaline, tumor necrosis factor (TNF-alpha), prostaglandin, leukotriene, enkephalin, bradykinin, vasopressin). Blood pressure, pulse rate, SPO2, heart rate variability and pain intensity on pre- and post-SGB.	—

Countries

Japan

Contacts

Public ContactHidetaka Kuroda

Kanagawa Dental University Hospital Department of Dental Anesthesiology

kuroda@kdu.ac.jp+81-46-822-8896

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026