Appropriate use of antibiotics using a serum procalcitonin 95%ile cutoff value for neonatal early-onset bacterial infections

Appropriate use of antibiotics using a serum procalcitonin 95%ile cutoff value for neonatal early-onset bacterial infections - Appropriate use of antibiotics using a serum procalcitonin 95%ile cutoff value for neonatal early-onset bacterial infections

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000051989

Enrollment

1350

Registered

2023-08-24

Start date

2020-03-06

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neonatal early-onset bacterial infection

Interventions

We included newborns admitted to our NICU who underwent blood tests within 72 hours after birth between 2018, and 2022. They were divided into the pre-intervention (those who admitted before the intro

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: We included newborns admitted to our NICU who underwent blood tests within 72 hours after birth between 2018, and 2022. They were divided into the pre-intervention (those who admitted before the introduction, n=737) or intervention (those who admitted after the introduction, n=686) groups

Exclusion criteria

Exclusion criteria: Death within 6 days after birth

Design outcomes

Primary

Measure	Time frame
Days of antibiotics therapy (DOT) per 1,000 patient-days up to 6 days after birth, newborn number (%) of usage antibiotics, and the incidence of early-onset bacterial infections	—

Countries

Japan

Contacts

Public ContactNobuhiko Nagano

Nihon University School of Medicine Department of Pediatrics and Child Health

nagano.nobuhiko@nihon-u.ac.jp+81-3-3972-8111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026