Schizophrenia
Conditions
Interventions
None listed
Sponsors
Showa University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: <Schizophrenic patient part> 1) Patients with schizophrenia who are hospitalized at the Department of Psychiatry, Showa University Karasuyama Hospital and meet DSM-5 diagnostic criteria 2) Patients who are between 20 and 60 years of age at the time of consent. 3) Patients who, after adequate explanation both orally and in writing, obtain consent from the patient if the attending physician determines that the patient is competent to consent, or from a surrogate if the patient is not. <Healthy volunteers Part> 1) Persons who are between 20 and 60 years of age at the time of obtaining consent 2) Persons who have given written consent to participate in this study
Exclusion criteria
Exclusion criteria: <Schizophrenic patient part> 1) Patients with a medical history (cerebral organic mental disorder, drug abuse dependence, alcohol abuse/dependence, malignancy, inflammatory bowel disease, heart disease, liver disease, chronic kidney disease, chronic obstructive pulmonary disease) that may affect the evaluation and safety of the study. 2) Those who have symptoms of xerostomia 3) Current smokers or those who have been non-smoking for less than 1 year 4) Subjects who have subjective symptoms of allergic diseases (asthma, atopic dermatitis) and are taking therapeutic drugs for them. 5) Persons who are judged to be ineligible by the physician in charge of the research. <Healthy volunteers Part> 1) Patients with a medical history (drug abuse/dependence, alcohol abuse/dependence, malignancy, inflammatory bowel disease, heart disease, liver disease, chronic kidney disease, chronic obstructive pulmonary disease) that may affect the evaluation and safety of this study 2) Persons who have been determined by the research physician to have a mental disorder using the Simple Structured Interview Method for Mental Disorders 3) Those who have symptoms of oral dryness 4) Those who are currently smoking or have been smoke-free for less than one year 5) Those who have subjective symptoms of allergic diseases(asthma, atopic dermatitis)and are taking medication to treat them 6) Persons who are judged to be ineligible by the physician in charge of the research
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Adiponectin levels in saliva and blood | — |
Secondary
| Measure | Time frame |
|---|---|
| Leptin, resistin, TNF-alpha, IL-6, IL-1beta, salivary chromogranin, salivary pH | — |
Countries
Japan
Contacts
Public ContactKiyomi Saito
Showa University School of Pharmacy
Outcome results
None listed