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Psychological stress-reducing effect of oral intake of gamma-aminobutyric acid (GABA): an updated systematic review with meta-analysis

Psychological stress-reducing effect of oral intake of gamma-aminobutyric acid (GABA): an updated systematic review with meta-analysis - Psychological stress-reducing effect of oral intake of gamma-aminobutyric acid (GABA): an updated systematic review

Status
Active, not recruiting
Phases
Unknown
Study type
Unknown
Source
JPRN
Registry ID
JPRN-UMIN000051927
Enrollment
Unknown
Registered
2024-12-31
Start date
2023-08-21
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy adults

Interventions

None listed

Sponsors

KAGOME CO., LTD.
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: (PICOS) Participant: We will include healthy adults without illness (excluding pregnant women [[including those planning to become pregnant and lactating women]. Intervention: Oral intake of test food containing GABA (regardless of the form and amount of intake) Comparison: Oral intake of test food without GABA, or no intervention Outcome measurement: Brain waves, heart rate variability, salivary markers (cortisol, alpha-amylase, chromogranin A, IgA), Profile of Mood States (POMS), Visual Analogue Scale (VAS) Study design: Randomized controlled parallel trials (RCT-P), randomized controlled crossover trials (RCT-C), quasi-randomized controlled parallel trials (qRCT-P), quasi randomized controlled crossover trials (qRCT-C), non-randomized controlled parallel trials (nonRCT-P), non-randomized controlled crossover trials (nonRCT-C), and non-randomized controlled trials (PECOS) Participant: We will include healthy adults without illness (excluding pregnant women [[including those planning to become pregnant and lactating women]. Exposure Oral intake of test food containing GABA (regardless of the form and amount of intake) Comparison: Oral intake of test food without GABA. If subgroup analysis of GABA intake amount has been conducted in a study, we define the least intake group as a non-exposure group. Outcome measurement: Brain waves, heart rate variability, salivary markers (cortisol, alpha-amylase, chromogranin A, IgA), Profile of Mood States (POMS), Visual Analogue Scale (VAS) Study design: Cohort studies and case-control studies. (Language) Eligibility is not restricted by language.

Exclusion criteria

Exclusion criteria: Exclude proceedings and unpublished studies which don't give us enough research details, and other gray documents that are difficult to verify.

Design outcomes

Primary

MeasureTime frame
Brain waves, heart rate variability, salivary markers (cortisol, alpha-amylase, chromogranin A, IgA), Profile of Mood States (POMS), Visual Analogue Scale (VAS)—

Countries

Japan

Contacts

Public ContactKazutaka Yoshida

KAGOME CO., LTD. Innovation Division

g167_0@kagome.co.jp0287-36-2935

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026