Postoperative anterograde amnesia by remimazolam and antagonism with flumazenil

Postoperative anterograde amnesia by remimazolam and antagonism with flumazenil - Postoperative anterograde amnesia by remimazolam and antagonism with flumazenil

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000051924

Enrollment

Registered

2023-08-18

Start date

2024-12-21

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients who will undergo general anesthesia for elective surgery of lower limbs

Interventions

administration of flumazenil administration of normal saline (placebo)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (1) Adult patient who will undergo elective surgery (2) Age 20-75 (3) No gender restriction (4) Patients who manifest consent for this study

Exclusion criteria

Exclusion criteria: (1) Patients contraindicate or with allergy to remimazolam or flumazenil (2) Patients contraindicate to neuraxial block (3) Patients with cognitive impairment (4) Patients with intracranial disease or cerebrovascular disease (5) Patients who take psychiatric medication (6) Patients who usually take benzodiazepine (7) ASAPS 3 or 4 (8) Patients decided not to be eligible for this study (9) Patients administrated flumazenil for clinical reason (not for research protocol)

Design outcomes

Primary

Measure	Time frame
Change of memory test by flumazenil	—

Secondary

Measure	Time frame
Time course of the score in memory test, Incidence of retrograde amnesia/ postoperative delirium/ postoperative sleep disorder	—

Countries

Japan

Contacts

Public ContactKotoe Kamata

Tohoku University Hospital Department of Anesthisiology

mattytohoku@gmail.com022-717-7321

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026