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Efficacy of orexin receptor antagonists for the prevention of delirium in cancer patients: a systematic review

Efficacy of orexin receptor antagonists for the prevention of delirium in cancer patients: a systematic review - Efficacy of orexin receptor antagonists for the prevention of delirium in cancer patients: a systematic review

Status
Active, not recruiting
Phases
Unknown
Study type
Unknown
Source
JPRN
Registry ID
JPRN-UMIN000051820
Enrollment
Unknown
Registered
2023-08-03
Start date
2023-09-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cancer

Interventions

None listed

Sponsors

Institute of Science Tokyo Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Patients with cancer (more than or equal to 80%) 2. Patients without delirium before intervention 3. Studies examining the efficacy or safety of orexin receptor antagonists for the prevention of delirium in adult cancer patients The study design to be considered for inclusion is as follows: 1. If there were at least two randomized controlled trial (RCT)s, inclusion was completed. 2. If there were less than 2 RCTs, we included non-RCTs or observational studies with control groups. 3. If there were no RCTs/non-RCTs/observational studies with control groups, single-arm observational studies were considered for inclusion.

Exclusion criteria

Exclusion criteria: 1. Duplicated publications 2. Conference proceedings 3. Reviews which are not based on systematic review 4. Study protocols 5. Case reports and case series 6. Articles written in languages other than English or Japanese

Design outcomes

Primary

MeasureTime frame
Incidence of delirium

Secondary

MeasureTime frame
1. Severity of delirium 2. Somnolence 3. Tumbling and falls

Countries

Japan

Contacts

Public ContactShuntaro Yasuda

Institute of Science Tokyo Hospital Department of Pharmacy

shun-yasuda@umin.ac.jp03-3813-6111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026