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Multicenter randomized Trial of expiratory training for Esophageal cancer patients undergoing neoadjuvant therapy

Multicenter randomized Trial of expIratory traininG for Esophageal canceR patientS undergoing neoadjuvant therapy - Tigers trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000051806
Enrollment
100
Registered
2023-08-08
Start date
2023-04-01
Completion date
Unknown
Last updated
2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Esophageal cancer

Interventions

Subjects will be 100 patients (intervention group: 50 patients, non-intervention group: 50 patients) scheduled for preoperative chemotherapy and radical resection for resectable advanced esophageal ca

Sponsors

Kasai Medical University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: (1)Patients with resectable advanced esophageal cancer (Stage II-IVA (12th edition of the Esophageal Cancer Treatment Protocol)) who are scheduled to undergo preoperative chemotherapy followed by subtotal esophagectomy and gastric tube reconstruction. (2) Patients who are 18 years of age or older on the date of enrollment. (3) Patients who can obtain written consent to participate in this study (4) Patients who are able to perform exhalation training with a balloon.

Exclusion criteria

Exclusion criteria: (1) Cases in which physical training is considered difficult to perform (2) Patients with difficulty in oral intake (nasal feeding tube inserted, dysphagia score 4) (3) Cases of combined pharyngolaryngectomy (4) Preoperative chemoradiotherapy cases (5) Patients with latex allergy (6) Other patients deemed inappropriate for the study by the physician in charge

Design outcomes

Primary

MeasureTime frame
Tongue pressure changes before and after chemotherapy

Countries

Japan

Contacts

Public ContactNobuyuki Yamamomo

Kasai Medical University Department of Upper Gastrointestinal Surgery

yamamoto.nby@kmu.ac.jp072-804-0101

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Sep 19, 2026