Sensorineural hearing loss
Conditions
Interventions
On the first day, an MRI measurement will be conducted, followed by brainwave (EEG) recording and transcranial magnetic stimulation with EEG recording in the primary auditory cortex within two months.
Sponsors
Kyoto University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: For individuals with normal hearing, there should be no self-awareness of hearing impairment and no indication of hearing loss in the past five years of health checkups. For individuals with hearing impairment, they will be classified into one of the following categories based on their hearing test results: mild hearing loss (25 dB or more and less than 40 dB), moderate hearing loss (40 dB or more and less than 70 dB), severe hearing loss (70 dB or more and less than 90 dB), or profound hearing loss (90 dB or more). No history of neurological disorders. Must have a physique that allows for wearing headgear.
Exclusion criteria
Exclusion criteria: Have difficulty understanding explanations or instructions due to cognitive impairments. Have a history of organic brain disorders or neurological diseases in the family. Have a pacemaker implanted. Already have a cochlear implant. Have non-ferromagnetic materials in the body that cannot be confirmed to be non-magnetic (such as aneurysm clips, mechanical heart valves, neural stimulation devices, insulin pumps, intraocular metals, etc.). If deemed unsuitable based on the "Transcranial Magnetic Stimulation (TMS) Examination Pre-checklist" and the "MRI Examination Pre-checklist." Any other individuals deemed inappropriate as research subjects by the principal investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Latency and Amplitude of Transcranial Evoked Potential, and Time Frequency Analysis Power | — |
Secondary
| Measure | Time frame |
|---|---|
| Amplitude and Time-Frequency Analysis Power of Resting-state and Auditory Stimulus Task-elicited Brain Waves, Latency of Evoked Brain Waves during Auditory Stimulus Task, and Changes in these Measures before and after Cochlear Implant Surgery. Correlation between Brain Wave Examination Results and Speech Discrimination Ability, Correlation between Cochlear Implant Thresholds and Speech Discrimination Ability at the Postoperative Six-month Mark, and Brain Wave Results. Functional Connectivity of Various Cortical Regions in Resting-state MRI and Changes in Connectivity before and after Cochlear Implant Surgery. Cognitive Function Evaluation (assessed with TMT, MMSE, and React Kyoto). | — |
Countries
Japan
Contacts
Public ContactKengo Oe
Kyoto University Graduate School of Medicine, Dept. of ORL-HNS
Outcome results
None listed