Kidney disease
Conditions
Interventions
18F-FAPI-74 PET/CT
Sponsors
Kobe City Medical Center General Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Those who are 18 years of age or older at the time of consent 2. Those who have undergone or will undergo a renal biopsy for the purpose of investigation of the renal disease as part of routine medical care within 30 days of the 18F-FAPI-74 PET/CT 3. Those who have undergone or will undergo an eGFRcys (cystatin C) blood test to evaluate renal disease for the purpose of investigation of the renal disease as part of routine medical care within 30 days of the 18F-FAPI-74 PET/CT 4. Those who can obtain written informed consent
Exclusion criteria
Exclusion criteria: 1. Those who are or may be pregnant 2. Those who have undergone or will undergo treatment for the disease between the 18F-FAPI-74 PET/CT and renal biopsy 3. Patients for whom furosemide administration is considered inappropriate by the referring physician 4. Patients for whom water intake is considered inappropriate by the referring physician 5. Those who are with severe claustrophobia 6. Those who are considered to be inappropriate to participate in this study by the principal investigator or sub-investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Relationship between renal 18F-FAPI-74 uptake and pathologic renal fibrosis indices | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Relationship between renal 18F-FAPI-74 uptake and FAP immunohistochemical findings 2. Relationship between renal 18F-FAPI-74 uptake and renal function (eGFRcys) | — |
Countries
Japan
Contacts
Public ContactTomohiko Yamane
Kobe City Medical Center General Hospital Molecular Imaging Research
Outcome results
None listed