Investigation of the usefulness of pulmonary oxygen consumption determined from indirect calorimetry and hemodynamic parameters in the evaluation of severe respiratory disease

Investigation of the usefulness of pulmonary oxygen consumption determined from indirect calorimetry and hemodynamic parameters in the evaluation of severe respiratory disease - Investigation of the usefulness of pulmonary oxygen consumption determined from indirect calorimetry and hemodynamic parameters in the evaluation of severe respiratory disease

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000051665

Enrollment

Registered

2023-08-01

Start date

2023-09-01

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients undergoing mechanical ventilation with tracheal intubation in the ICU due to severe respiratory disease

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Forty-three adult patients who were intubated and mechanically ventilated in the ICU of our hospital for severe respiratory disease and who met all of the following criteria: 1) An arterial catheter is inserted 2) Central venous blood gas analyses for respiratory status are performed

Exclusion criteria

Exclusion criteria: Exclude patients and timings with any of the following: 1) Measurements obtained during mechanical circulatory support 2) Patients with an arteriovenous shunt 3) Timing within 10 minutes after changing ventilator settings 4) Cardiogenic pulmonary edema is determined to be the main cause of worsening respiratory status, or patients undergoing blood gas analysis from a CV catheter to evaluate respiratory status. 5) uring clinically significant arrhythmias

Design outcomes

Primary

Measure	Time frame
In this study, we mainly examine three items: 1) the relationship between mortality and delta VO2, 2) the relationship between delta VO2 and the P/F ratio 3) the relationship between changes in delta VO2 (delta-delta VO2) and changes in the P/F ratio (delta P/F).	—

Secondary

Measure	Time frame
# Relationship between delta VO2, ScvO2, and O2 extraction rate (O2ER) # Relationship between delta VO2 and CRP # Relationship between delta VO2 and days of mechanical ventilation, length of stay in ICU, reintubation rate, SBT success/failure rate, and RSBI (SBT: Spontaneous breathing trial, RSRI: Rapid Shallow Breathing Index)	—

Countries

Japan

Contacts

Public Contactkeisuke Yoshida

Fukushima Medical University Department of Anesthesiology

masui@fmu.ac.jp0245471342

Outcome results