Chromoendoscopy using the non-extension sign as a marker is comparable to endoscopic ultrasonography in terms of diagnostic performance for evaluating the invasion depth of early colorectal cancer

Chromoendoscopy using the non-extension sign as a marker is comparable to endoscopic ultrasonography in terms of diagnostic performance for evaluating the invasion depth of early colorectal cancer - Chromoendoscopy using the non-extension sign as a marker is comparable to endoscopic ultrasonography in terms of diagnostic performance for evaluating the invasion depth of early colorectal cancer

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000051603

Enrollment

Registered

2023-07-13

Start date

2020-11-09

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

early colorectal cancer

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (1) patients with early colorectal cancer who underwent endoscopic or surgical resection at Fukuoka University Chikushi Hospital between January 2010 and April 2020 whose resected specimens were available for detailed histopathological examination and (2) patients in whom the modalities of CE using the NES as a marker, M-NBI, M-CE using crystal violet staining, and EUS were performed for diagnosing invasion depth during preoperative examination.

Exclusion criteria

Exclusion criteria: (1) patients in whom any of the modalities was difficult to perform and (2) patients whose lesions were difficult to visualize by EUS.

Design outcomes

Primary

Measure	Time frame
To compare diagnostic performance (sensitivity, specificity, and accuracy) for evaluating the invasion depth of T1b cancer between CE using the NES as a marker and EUS.	—

Secondary

Measure	Time frame
To determine the additive effect of EUS for correctly diagnosing patients in whom the invasion depth of T1b cancer was misdiagnosed by CE, to compare the diagnostic performance (sensitivity, specificity, and accuracy) of CE and magnifying endoscopy (M-NBI and M-CE) in evaluating the invasion depth of T1b cancer, and to determine the additive effect of magnifying endoscopy (M-NBI and M-CE) for correctly diagnosing patients in whom the invasion depth of T1b cancer was misdiagnosed by CE.	—

Measure

Time frame

To determine the additive effect of EUS for correctly diagnosing patients in whom the invasion depth of T1b cancer was misdiagnosed by CE, to compare the diagnostic performance (sensitivity, specificity, and accuracy) of CE and magnifying endoscopy (M-NBI and M-CE) in evaluating the invasion depth of T1b cancer, and to determine the additive effect of magnifying endoscopy (M-NBI and M-CE) for correctly diagnosing patients in whom the invasion depth of T1b cancer was misdiagnosed by CE.

—

Countries

Japan

Contacts

Public ContactKazuhiro Takeda

Fukuoka University Chikushi Hospital Endoscopy

newzealand_greg@yahoo.co.jp092-921-1011

Outcome results