A investigation of the correlation between the distribution of local anesthetic and the sensory area of modified thoracoabdominal nerves block through perichondrial approach (M-TAPA): a volunteer study

A investigation of the correlation between the distribution of local anesthetic and the sensory area of modified thoracoabdominal nerves block through perichondrial approach (M-TAPA): a volunteer study - A investigation of the correlation between the distribution of local anesthetic and the sensory area of modified thoracoabdominal nerves block through perichondrial approach (M-TAPA): a volunteer study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000051586

Enrollment

Registered

2023-10-01

Start date

2024-01-26

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

healthy adult male volunteers

Interventions

Performing bilateral M-TAPA using 0.15% levobupivacaine 25mL, epinephrine 0.13mL, and contrast (gadobutrol) approximately 0.4mL per side.

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: Healthy adult male volunteers with ASA-PS I. Persons who voluntarily participate in this study with sufficient informed consent.

Exclusion criteria

Exclusion criteria: 1. History of asthma 2. Allergy or hypersensitivity to research-related drugs 3. Patients with a history of trauma or surgery involving the muscular layer in the thoracoabdominal area 4. Patients who already have sensory abnormality in the thoracoabdominal area 5. Those who are unable to undergo MRI imaging due to claustrophobia, presence of metal in the body, etc. 6. Those who weigh less than 50 kg or have a BMI of 25 or more. 7. Patients with anatomical abnormalities at the puncture sites that may pose a risk 8. Patients with severe renal, hepatic, or hemostatic functional disorders, etc. 9. Patients taking antithrombotic drugs 10. Other subjects who are deemed inappropriate as research subjects by the principal investigator.

Design outcomes

Primary

Measure	Time frame
The correlation between the sensory area and subcutaneous local anesthetic distribution confirmed by pinprick test and MRI at 60 and 120 min after M-TAPA.	—

Secondary

Measure	Time frame
The adverse events associated with M-TAPA The duration of Analgesia	—

Countries

Japan

Contacts

Public ContactAikawa Katsuhiro

Hokkaido University Hospital Department of Anesthesiology

katsuhiro.aikawa@med.hokudai.ac.jp0117067861

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026