essential hypertension
Conditions
Interventions
Administration of sacubitril valsartan for one year
Administration of valsartan for one year
Sponsors
University of Toyama
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patient with untreated essential hypertensiont 2) Patient who is between 20 and 70 years old 3) Patient who can freely give consent under a good understanding of the explanation
Exclusion criteria
Exclusion criteria: 1) Patient under 20 years old or over 70 years old 2) Patient receiving angiotensin converting enzyme or within 36 hours of its discontinuation 3) Diabetic patient receiving aliskiren fumarate 4) Patient with severe hepatic impairment (Child-Pugh class C) 5) Pregnant woman or woman who may be pregnant 6) Patient judged by the research physician to be unsuitable for inclusion
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in blood pressure and indices of sympathoadrenal system (plasma catecholamines, power spectrum analysis obtained from heart rate variability measured by Holter ECG) during mental arithmetic stress before and after treatment (sacubitril-valsartan or valsartan administration) | — |
Countries
Japan
Contacts
Public ContactTsutomu Koike
University of Toyama The Second Department of Internal Medicine
Outcome results
None listed