Adult
Conditions
Interventions
Blood samples are collected at 6 time points after Brazilian green propolis ( 360 mg ) ingestion with each of 9 beverages. The experimental periods are separated by at least 72 hours as a washout peri
Sponsors
Yamada Bee Company, Inc.
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Healthy Japanese men and women aged between 20 and 45 at the time of informed consent. 2. BMI:18.5 - 25.0
Exclusion criteria
Exclusion criteria: 1. Subjects who have history of food allergies. 2. Subjects who have history of asthma. 3. Subjects in pregnancy or in nursing. 4. Subjects who had participated in other clinical trial within 12 weeks. 5. Subjects who have a history of the surgery considerable in the gastrointestinal tract site, for example, gastrectomy, gastrointestinal suturing, intestinal resection and so on. 6. Subjects with a current or history of serious illness, such as diabetes, liver disease, kidney diseases, heart diseases, and more. 7. Subjects who have taken medication treatment. 8. Subjects who can not refrain from eating and drinking except for designated meals from the dinner before the examination to the end of the examination. 9. Subjects who can not quit smoking from dinner on the day before the examination to the end of the examination. 10. Subjects who can not take the test food as instructed and can not maintain rest until the end of the study. 11. Subjects who can not prohibit intake of foods, medicines and supplements containing propolis or flavonoid before one week at the start of this study. 12. Subjects who can not continue regular life. 13. Subjects who have an irregular habit because of working at night or working under work-shift form. 14. Subjects who have taken the blood sampling either 200 mL within 4 weeks or 400 mL within 3 months. 15. Subjects who are heavy drinker(>500 mL beer per day). 16. Subjects who are smoking more than 20 cigarettes per day. 17. Subjects who are judged as unsuitable for the current in this study by the study director.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma concentration and the area under the plasma concentration -time curve of propolis components. | — |
Countries
Japan
Contacts
Public ContactYuki Haruna
Yamada Bee Company, Inc. Yamada Bee Company Institute for Bee product & Health Science, R&D department.
Outcome results
None listed