Comparison of the preventive effect of ondansetron and dexamethasone on nausea and vomiting after orthognathic surgery between remimazolam and propofol anesthesia.

Comparison of the preventive effect of ondansetron and dexamethasone on nausea and vomiting after orthognathic surgery between remimazolam and propofol anesthesia. - Comparison of the preventive effect of ondansetron and dexamethasone on nausea and vomiting after orthognathic surgery between remimazolam and propofol anesthesia.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000051512

Enrollment

Registered

2023-07-03

Start date

2023-07-04

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients undergoing orthognathic surgery

Interventions

In the propofol group, anesthesia is induced with continuous infusion of propofol at a rate of 4.0 mcg/ml (target effect-site concentration) until loss of consciousness and maintained with a BIS value

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Eligible patients meet the criteria of the ASA-PS of 1-2.

Exclusion criteria

Exclusion criteria: Under 20 years of age, ASA-PS3 or higher, patient consent not obtained, BMI30 or higher, use of antiemetics within 24h before surgery, taking benzodiazepines, contraindicated for administration of medications used in this study, emergency surgery

Design outcomes

Primary

Measure	Time frame
Postoperative nausea attitude,Frequency of vomiting(immediately after the end of anesthesia,2 hours later,24h hours later)	—

Secondary

Measure	Time frame
Whether to use rescue anti-emetics (metoclopramide) The quality of recovery	—

Countries

Japan

Contacts

Public ContactAi Nakakuki

Tokyo Dental College Dental Anesthesiology

anakakuki@tdc.ac.jp03-6380-9001

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026