Epilepsy, Parkinson'
Conditions
Interventions
Presentation of taVNS (up to 1 day in healthy adults and epilepsy group, up to 5 days in patients with implanted electrodes)
Sponsors
Jichi Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Epileptic patients. Normal adults. For normal adults, patients between the ages of 18-65 years with no diagnosed congenital or developmental disorders. Patients with refractory epilepsy who will undergo intracranial electrode placement to identify the epileptic focal area. Patients with Parkinson's disease, dystonia, essential tremor, stroke-induced movement disorder, stroke aftereffects, or involuntary movement disorder who are undergoing deep brain stimulation therapy to relieve symptoms of the above diseases.
Exclusion criteria
Exclusion criteria: Exclusion criteria for patients and healthy adults undergoing functional magnetic resonance imaging testing 1. people who have a pacemaker implanted in their body. 2. people who have metal in their body for surgery or drug injection. 3. people who may have accidentally received a piece of metal in their body from working in the metal processing industry, etc. 4. people who are claustrophobic. 5. People who experience severe shortness of breath when lying down.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Differences in brain activity (BOLD signal intensity in cortical and subcortical regions) at rest and during cognitive tasks during taVNS stimulation will be compared between epileptic patients and healthy controls. | — |
Secondary
| Measure | Time frame |
|---|---|
| Brain activity (BOLD signal intensity and local potentials) at rest and during cognitive task loading were compared before and during taVNS stimulation using functional timing image resonance and local potential measurements. The results of behavioral indices of cognitive tasks are compared before and during taVNS stimulation. | — |
Countries
Japan
Contacts
Public ContactKensuke Kawai
Jichi Medical University Department of Neurosurgery
Outcome results
None listed