Healthy adult
Conditions
Interventions
1: Pre-exposure sleep experiment. Phenylethyl alcohol (rose-like odor) will be presented during nocturnal sleep at a sleep chamber of laboratory. 2: Repeted exposure for Phenylethyl alcohol to induce
Sponsors
National Center of Neurology and Psychiatry
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Subjective ratings on 1-9 scales of Phenylethyl alcohol and Eugenol at screening are as follows: preference is middle (3-7 points), familiarity is low (<=6 points). 2) 20<= and 25>= years old. 3) No sleep disorder, olfaction/taste disorder and no history. 4) No sleep disorder was susupected by PSG at adaptation night. 5) Not taking medications that affect sleep, olfaction/taste.
Exclusion criteria
Exclusion criteria: 1) Having difficulty in filling out Japanese explanatory documents, consent forms, and survey forms. 2) Who cannot stay in the sleep chamber of National center of neurology and psychiatry. 3) Who have specific episodic memory about Phenylethyl alcohol and eugenol, confirmed at screening. 4) No improvement of preference and familiarity ratings through odor exposure. 5) Persons at high risk person developing dermatitis due to experimental equipments or alcohol cotton for attach the electrodes. 6) Persons with claustrophobia. 7) Patients who may have sudden changeable sickness or have a history. 8) Patients who have mental disorders diagnosis/treatment or have a history. 9) Women who are or may be pregnant. 10) Lactating women. 11) Any other person judged by the investigator to be inappropriate as a subject.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Amygdala activitiy during REM sleep estimated from EEG | — |
Countries
Japan
Contacts
Public ContactSatomi Okabe
National Center of Neurology and Psychiatry Department of sleep-wake disorders, National institute of mental health
Outcome results
None listed