Depression, anxiety, obsessive-compulsive disorder, anorexia nervosa, bulimia nervosa, autism spectrum disorder, attention-deficit/hyperactivity disorder
Conditions
Interventions
Cognitive Tasks 1) Stop-Signal Task 2) Comprehensive Ability Battery-Spatial (CAB-S) 3) Vandenberg &
Kuse Mental Rotation Test
Sponsors
Chiba University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Selection Criteria for Patient Groups 1) Patients will be selected by using the Mini-International Neuropsychiatric Interview (M.I.N.I.), and the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-R or DSM-5). 2) The patient has residual symptoms of moderate severity or greater. 3) Symptoms in 1) are the main obstacle in the patient's life and other comorbidities are acceptable as long as they are secondary. 4) Patients must be at least 18 years of age. 5) Patients who have been fully informed of the study and have given their free and voluntary written consent based on a full understanding of the study. Rationale: 1-2) To identify the target disease. 3) To reflect the clinical picture by recognizing comorbidities as much as possible. 4-5) To consider safety and ethical aspects. Selection criteria for the subthreshold anxiety group 1) Patients with no history of psychiatric disorders and no current symptoms 2) Patients who do not meet the criteria for a psychotic episode on the M.I.N.I. 3) LSAS score of 50 or higher 4) Age 18 years or older. 5) The patient must have been fully informed of the study and must have given his/her free and voluntary written consent based on a thorough understanding of the study. Rationale: 1-3)To identify the subjects. To reflect the clinical picture by recognizing comorbidities as much as possible. 4-5) To consider safety and ethical aspects. Selection Criteria for Healthy Subjects 1) No history of psychiatric disorders and no current symptoms 2) Age 18 years or older. 3) Participants who have been fully informed of the study and who have given written consent of their own free will based on a thorough understanding of the study. Rationale: 1) To identify the target population. To recognize comorbidities as much as possible to better reflect the clinical picture. 2-3) To consider safety and ethical aspects.
Exclusion criteria
Exclusion criteria: 1) Those at imminent risk of suicide 2) Those with antisocial personality disorder 3) Patients with serious mental disorders that may require hospitalization. 4) Patients who cannot give their free and voluntary written consent after receiving a full explanation of their participation in this study and with full understanding. 5) Other subjects deemed inappropriate by the PI. [Rationale] 1-5) For ethical and safety considerations.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The overall target number of patients is 280. This includes 196 patients with psychiatric disorders (depression, anxiety, obsessive-compulsive disorder, anorexia nervosa, bulimia nervosa, autism spectrum disorder, and attention-deficit/hyperactivity disorder) and 28 patients in the subthreshold anxiety group. In addition, the number of healthy subjects will be 56. Because of the wide range of cognitive impairments in each disease, the effect size was set to be small (0.2) and the dropout rate was expected to be 10%, resulting in 28 subjects in each group. The number of healthy participants was set at 56, in order to match the age and gender of the participants with each disease, and to provide a comparison group. Over a two-year period, it is expected to obtain data from half of the participants. | — |
Countries
Japan
Contacts
Public ContactSertap Maral
Chiba University Research Center for Child Mental Development
Outcome results
None listed