Prospective observational study of the effects of D-alanine intake on amino acid metabolism

Prospective observational study of the effects of D-alanine intake on amino acid metabolism - D-alanine intake studies in healthy adults

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000051466

Enrollment

Registered

2023-06-28

Start date

2023-06-27

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic kidney disease

Interventions

Oral intake of D-alanine 3 g per day for 7 days Oral intake of D-alanine 6 g per day for 7 days

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Persons are included if they meet all of the following criteria; 1) Aged 20 years or over 2) Agree to participate in this study

Exclusion criteria

Exclusion criteria: Persons are excluded if they meet any of the following criteria; 1) Pregnant or lactating 2) Judged by physicians to be unsuitable as participants

Design outcomes

Primary

Measure	Time frame
Changes in serum and urine DL-amino acids at 7 days after D-alanine intake initiation	—

Secondary

Measure	Time frame
1) Changes at 7 days after D-alanine intake initiation; blood glucose, HbA1c, blood pressure, body mass index (BMI), estimated GFR, urine protein/creatinine ratio, urine beta2-microglobulin, urine N-acetyl-beta-D-glucosaminidase 2) Adverse events	—

Countries

Japan

Contacts

Public ContactMegumi Oshima

Kanazawa University Department of Nephrology and Laboratory Medicine

moshima@staff.kanazawa-u.ac.jp+81-76-265-2499

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026