Observational study on reduction of intra-amniotic inflammation by antimicrobial treatment in cases of preterm premature rupture of membranes with intra-amniotic infection.

Effect of Maternal Steroid and Antimicrobial Administration on Amniotic Fluid IL-6 Levels - Effect of antimicrobial treatment on amniotic fluid IL-6 levels

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000051403

Enrollment

103

Registered

2023-06-28

Start date

2021-10-23

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intra-amniotic infection

Interventions

None listed

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Singleton pregnancy patients who developed PPROM between 22 gestational weeks and 0 days and 33 gestational weeks 6 days (from August 2014 to April 2020).

Exclusion criteria

Exclusion criteria: Patients with an unclear time of membrane rupture, patients who underwent amniocentesis after amnioinfusion, patients who underwent amniocentesis more than 24 h after being diagnosed with PPROM, patients with unclear results of amniotic fluid culture, patients diagnosed with IAI alone or MIAC alone, patients who delivered <7 days after being diagnosed with PPROM, patients who were not administered previously arranged antibiotics, patients who did not undergo follow-up amniocentesis for any reason, and patients without either IAI or MIAC who had the secondary intra-amniotic infection before follow-up amniocentesis.

Design outcomes

Primary

Measure	Time frame
The change and rate of change in amniotic fluid IL-6 levels between the initial and follow-up amniocentesis	—

Secondary

Measure	Time frame
The changes in the load of Ureaplasma spp. DNA in the amniotic fluid between the initial and follow-up amniocentesis	—

Countries

Japan

Contacts

Public ContactMakoto Nomiyama

National Hospital Organization, Saga National Hospital Department of Obstetrics and Gynecology

nomiyama8522@gmail.com0952307141

Outcome results