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Low-dose tranexamic acid regimen in cardiac surgery

Efficacy and safety profile of low-dose tranexamic acid regimen in cardiac surgery: A meta-analysis - Low-dose tranexamic acid regimen in cardiac surgery

Status
Active, not recruiting
Phases
Unknown
Study type
Unknown
Source
JPRN
Registry ID
JPRN-UMIN000051380
Enrollment
100
Registered
2023-06-19
Start date
2023-02-09
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

all randomized trials examining the bleeding-reducing effect of tranexamic acid in open-heart surgery

Interventions

None listed

Sponsors

Faculty of Medicine, Universitas Surabaya
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: all randomized trials examining the bleeding-reducing effect of tranexamic acid in open-heart surgery based

Exclusion criteria

Exclusion criteria: We excluded studies that did not have the outcomes we wanted and those that did not have comparisons between low-dose regimens and placebo or high-dose regimens.

Design outcomes

Primary

MeasureTime frame
The primary outcome of this meta-analysis was safety issues, namely the level of adverse events, including mortality, bleeding-associated re-surgery, myocardial infarction, venous thromboembolic events (VTE), stroke, and seizures.—

Secondary

MeasureTime frame
Secondary outcomes included efficacy issues in the form of the amount of bleeding in 24 h, the number of PRC unit transfusions in 24 h, intensive care unit (ICU) stay, and length of hospital stay.—

Countries

Asia(except Japan)

Contacts

Public ContactArdyan Wardhana

Universitas surabaya Faculty of Medicine

ardyanwardhana@staff.ubaya.ac.id6282138433032

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026