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Elucidation of induction of intra-abdominal fatty inflammation after surgery and inhibitory effect of insulin on fatty inflammation.

Elucidation of induction of intra-abdominal fatty inflammation after surgery and inhibitory effect of insulin on adipose tissue-derived inflammation. - Elucidation of inhibitory effect of insulin on perioperative adipose tissue-derived inflammation.

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
JPRN
Registry ID
JPRN-UMIN000051342
Enrollment
5
Registered
2023-06-15
Start date
2023-09-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients who are candidates for gastrointestinal surgery

Interventions

None listed

Sponsors

National Hospital Organization Higashi Ohmi General Medical Center
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1) ECOG Performance Status is 0-1 2) Over 20 years of age. 3) Patients who explained the purpose and contents of this study to the patient and their families, and obtained their voluntary consent to the study.

Exclusion criteria

Exclusion criteria: 1) Patients with serious organ damage (cardiac disease, respiratory disease, liver cirrhosis, renal failure, etc.) 2) Patients with a life expectancy of at least 1 month 3) Others who are judged to be unsuitable as patients by the investigator or investigator

Design outcomes

Primary

MeasureTime frame
Changes in adipocytokine secretion ability of visceral fat (collected before abdominal closure) by insulin administration.

Secondary

MeasureTime frame
1) Changes over time in adipocytokines (visfatin, adiponectin, free fatty acids) secreted from adipose tissue 2) Changes in adipocytokine secretion ability of adipose tissue by endogenous inflammatory cytokines (TNF alpha, IL-6, TGF beta) stimulation

Countries

Japan

Contacts

Public ContactHiroya Akabori

National Hospital Organization Higashi Ohmi General Medical Center Department of Surgery

hakabori@belle.shiga-med.ac.jp0748223030

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026