Response to Fibrinogen Replacement Therapy in DIC and Non-DIC Patients with Obstetric Massive Hemorrhage: A Single-Center Observational Study

Response to Fibrinogen Replacement Therapy in DIC and Non-DIC Patients with Obstetric Massive Hemorrhage: A Single-Center Observational Study - Response to Fibrinogen Replacement Therapy in DIC and Non-DIC Patients with Obstetric Massive Hemorrhage: A Single-Center Observational Study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000051296

Enrollment

Registered

2023-06-10

Start date

2023-06-10

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Women who delivered at Juntendo University Hospital between April 2015 and October 2021 who were declared obstetric massive hemorrhage and treated with fibrinogen replacement therapy

Interventions

None listed

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Women who gave birth at Juntendo Hospital between April 2015 and October 2021 who were declared obstetric massive hemorrhage and treated with fibrinogen replacement therapy

Exclusion criteria

Exclusion criteria: Patients with congenital hypofibrinogenemia, pregnancy <22 weeks, measurement errors, missing data, and patients transported from other hospitals who had received antithrombin or recombinant active clotting factor VII were excluded.

Design outcomes

Primary

Measure	Time frame
Elevated fibrinogen levels by FRT in DIC and non-DIC groups	—

Secondary

Measure	Time frame
Blood coagulation data including fibrinogen levels before and after FRT, Blood loss and transfusion volume before and after FRT, Time from onset of bleeding to hemostasis, Time from start of treatment to hemostasis	—

Countries

Japan

Contacts

Public ContactHisako Okada

Juntendo University Urayasu Hospital Department of Anesthesiology and Pain Medicine

h-okada@juntendo.ac.jp0473533111

Outcome results