A double-blind, randomized controlled trial study on the preventive effect of cetylpyridinium chloride containing mouthwash on gingivitis during orthodontic treatment

A double-blind, randomized controlled trial study on the preventive effect of cetylpyridinium chloride containing mouthwash on gingivitis during orthodontic treatment - Verification of the preventive effect of cetylpyridinium chloride-containing mouthwash on gingivitis during orthodontic treatment

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000051198

Enrollment

Registered

2023-06-13

Start date

2023-07-11

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

gingivitis

Interventions

Use a cetylpyridinium chloride-containing mouthwash during orthodontic treatment. A placebo solution of cetylpyridinium chloride-containing mouthwash is used during orthodontic treatment.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Subjects with malocclusion who will start orthodontic treatment using multi-bracket appliances 2. Age between 15 and 40 at the time of consent form acquisition 3. Subjects who can obtain written consent from the person regarding participation in this research

Exclusion criteria

Exclusion criteria: 1. Subjects with congenital anomalies such as cleft lip and palate 2. Subjects with diseases such as gingivitis and caries 3. Subjects with systemic diseases or medications that interfere with treatment 4. Subjects who habitually use mouthwash 5. Others who are deemed inappropriate by the principal investigator or co-investigator

Design outcomes

Primary

Measure	Time frame
bleeding on probing	—

Countries

Japan

Contacts

Public ContactIsamu Kado

Hiroshima University Graduate School of Biomedical and Health Sciences Department of Orthodontics and Craniofacial Developmental Biology

isamu-kado@hiroshima-u.ac.jp082-257-5685

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026