Habitual cigarette smoking may be associated with a lower total serum bilirubin level leading to higher inflammation: A cross-sectional study

Association of cigarette smoking habits and total serum bilirubin on inflammation - Association of cigarette smoking habits and total serum bilirubin on inflammation

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000051136

Enrollment

10000

Registered

2023-06-01

Start date

2023-06-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Participants receiving annual health check

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: This cross-sectional study focused on the primary prevention of ASCVD, examining the relationship between fish consumption, lifestyle, TSB, and inflammation. Among 11,678 Japanese individuals over 20 years who underwent annual health checkups between April 2019 and March 2020 at the Health Planning Center of Nihon University Hospital.

Exclusion criteria

Exclusion criteria: unwillingness to provide informed consent for participation, positive history of ASCVD, C-reactive protein (CRP)levels more than 2.0 mg/dL, the presence of hepatitis B virus surface antigen, hepatitis C antibodies, hepatic cirrhosis, hepatocellular carcinoma, and metastatic liver cancer or no measurement of leukocyte and leucocyte subclass count, CRP levels, and TSB levels. We also excluded participants with TSB levels of more than 2.0 mg/dL to exclude constitutional jaundice as much as possible.

Design outcomes

Primary

Measure	Time frame
The primary endpoint is the relationship between cigarette smoking habits and TSB.	—

Secondary

Measure	Time frame
The secondary endpoint is the relationship between unhealthy lifestyle habits related to cigarette smoking habits and TSB.	—

Countries

Japan

Contacts

Public ContactShigemasa Tani

Nihon University Hospital Health Planning Center

tani.shigemasa@nihon-u.ac.jp0332931711

Outcome results