Diagnostic accuracy of Murray law based quantitative flow ratio in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement

Diagnostic accuracy of Murray law based quantitative flow ratio in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement - Diagnostic accuracy of Murray law based quantitative flow ratio in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000051134

Enrollment

Registered

2023-05-23

Start date

2018-08-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aortic stenosis, coronary artery disease

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1 patients with moderate or greater (30-90%) stenotic lesions on gross evaluation using coronary CT angiography and coronary angiography prior to TAVR. 2 patients aged > 20 years at the time of diagnosis.

Exclusion criteria

Exclusion criteria: 1. Patients with hemodynamic instability 2. History of acute myocardial infarction within two months 3. Patients with major procedural complications, such as death, brain stroke, acute myocardial infarction with the exception of permanent pacemaker implantation. 4. Patients who underwent percutaneous coronary angioplasty or coronary artery bypass grafting for severe coronary artery stenosis during perioperative TAVR. 5. Patients with metal stent implanted in the left main trunk 6. Patients with left main trunk stenosis > 30% and one or more metal stents implanted in the left coronary artery. 7. Patients with more than one coronary artery with a metal stent 8. Patients who underwent coronary artery bypass grafting 9. Patients with chronic total occlusion in any of the major coronary arteries on coronary angiography 10. Patients with artifacts or contrast defects severe enough to interfere with coronary CT angiography were deemed unreadable by institutional evaluation. 11. Patients in whom it was expected to have anatomical difficulty in passing wires through the coronary arteries. 12. Patients who refused to participate in the study 13. In other cases, the investigator determined that the participant was inappropriate for the study.

Design outcomes

Primary

Measure	Time frame
The primary outcome of this study was the diagnostic performance of pre-TAVR murray based law quantitative flow ratio without nitroglycerin. Post-TAVR invasive FFR < 0.8 was used as a reference standard of ischemia.	—

Secondary

Measure	Time frame
The secondary endpoints were the diagnostic performance of pre- and post-TAVR iFR, pre-TAVR QFR, and post-TAVR murray based law quantitative flow ratio.	—

Countries

Japan

Contacts

Public ContactHiromasa Ohtake

Kobe University Hospital, School of Medicine Division of Cardiovascular Medicine

hotake@med.kobe-u.ac.jp078-382-5846

Outcome results