None
Conditions
Interventions
Low intensity exercise (40% VO2 peak) with ergometer for 5 consecutive days
Vigorous intensity exercise (60% VO2 peak for day 1, 65% for day 2, and 70% for days 3-5) with ergometer
Sponsors
Juntendo University Graduate School of Medicine Department of Metabolism & Endocrinology
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: Japanese men, aged 20 years and older, BMI over 23, fitness habits less than one time per week, no medical treatment. On the screening session, blood samples were taken after an overnight fast to measure triglycerides (TG), HDL cholesterol (HDL-C), and fasting plasma glucose (FPG). Arterial blood pressure (BP), height, and weight were also measured. Based on the Japanese definition of metabolic syndrome, three cardiovascular metabolic risk factors were defined as hyperglycemia (FPG 110 mg/dL or higher), dyslipidemia (TG above 150 mg/dL and/or HDL-C less than 40 mg/dL), and hypertension (BP of 130/85 mm Hg or higher ) and have at least one of these and insulin resistance HOMA-IR 1.6 or higher (abnormal insulin sensitivity in Japan)
Exclusion criteria
Exclusion criteria: (1) People with diabetes mellitus. (2)Excessive and habitual drinkers. (3) Serious liver dysfunction (4)Persons with serious renal disease (5)Persons with cardiovascular diseases such as arrhythmic disease or ischemic heart disease. (6)Persons with serious pancreatic diseases. (7) Patients with cancer. (8) Those infected with hepatitis B virus or hepatitis C virus. (9) Patients with serious infectious diseases or serious trauma. (10) Patients before or after surgery. (10) Patients with inflammatory bowel disease, colorectal ulcer, local bowel obstruction, or predisposition to bowel obstruction. (11) Patients who are allergic to local anesthesia. (12) Persons who do not meet the safety requirements for MRI experiments. (13) Subjects who are deemed inappropriate by the examining physician.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in intramyocellular lipids and insulin sensitivity by exercise intervention. | — |
Secondary
| Measure | Time frame |
|---|---|
| intrahepatic lipid content fasting blood glucose free fatty acid plasma insulin serum adiponectin muscle and serum lipid composition muscle gene expression levels body weight body fat Percentage | — |
Countries
Japan
Contacts
Public ContactTakashi FUNAYAMA
Juntendo University Graduate School of Medicine Department of Metabolism & Endocrinology
Outcome results
None listed