Glaucoma
Conditions
Interventions
None listed
Sponsors
Tohoku University Graduate School of Medicine
Seiryo Eye Clinic
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients with normal tension glaucoma (Intraocular pressure of 16 mmHg or below) 2. Individuals who are suspected to be affected by progressive visual field defect as indicated in Humphrey visual field test despite pharmaceutical treatment 3. Individuals who are diagnosed with SAS as a result of scoring 20 or more in AHI and are considered patients that need CPAP therapy 4. Glaucoma patients of all disease stages
Exclusion criteria
Exclusion criteria: 1. Outpatients periodically attending ophthalmology check-up due to severe eye condition 2. Individuals who plan to undergo surgery for glaucoma during observation period 3. Individuals with high myopia (Axial length of 26.5 mm or above and spherical equivalent of -8D or above) 4. Individuals who have undergone LASIK 5. Individuals who have undergone ophthalmologic surgery in the last three months 6. Individuals suffering from cancer 7. Individuals suffering from hormonal disorder (e.g. autoimmune disease, hyperthyroidism) 8. Individuals who are taking oral contraceptive pill 9. Individuals who are pregnant, or planning pregnancy or breastfeeding during study period 10. Individuals who are deemed ineligible for participation by the principal investigator or co-investigator due to other reasons 11. Individuals who are currently receiving CPAP therapy 12. Individuals who did not give informed consent or decline disclosure of research information
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The rate of change of glaucoma progression associated with CPAP therapy (Mean Deviation slope (MD slope) using Humphrey Field Analyzer (HFA) 24-2) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Severity of sleep SAS at diagnosis 2. Apnea Hypopnea Index (AHI) before CPAP therapy 3. AHI during CPAP therapy 4. Number of hours CPAP therapy used /Number of days CPAP therapy used 5. Biomarkers of oxidative stress (e.g. diacron reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP)) 6. Ophthalmological examination (Refraction, corneal curvature radius, axial length, corneal thickness, corneal elasticity, visual acuity, intraocular pressure, ophthalmoscopy, three-dimensional image analysis of ocular fundus, visual field test, optical coherence tomography angiography, laser speckle flowgraphy) 7. Vital signs (Blood pressure, pulse rate, peripheral oxygen saturation (SpO2)) | — |
Countries
Japan
Contacts
Public ContactNoriko Himori
Tohoku University Graduate School of Medicine Department of Ophthalmology
Outcome results
None listed