A role of transcutaneous vagus nerve stimulation on left ventricular function and afterload in Takotsubo syndrome

A role of transcutaneous vagus nerve stimulation on left ventricular function and afterload in Takotsubo syndrome - Vagus nerve stimulation and left ventricle in Takotsubo syndrome

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000051017

Enrollment

Registered

2023-06-01

Start date

2023-05-31

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Takotsubo syndrome

Interventions

In the active LLTS precedent group, a device clip is attached to the left tragus, and stimulation was performed for 1 hour as vagus nerve auricular stimulation. In the Sham stimulation precedent group

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1. The patients diagnosed as Takotsubo syndrome in Hiroshima City Asa Hospital 2. The Takotsubo syndrome patients who have systolic blood pressure more than 100mmHg. 3. The Takotsubo syndrome patients who provide written informed consent.

Exclusion criteria

Exclusion criteria: 1. The Takotsubo syndrome patients who have multiple organ failure. 2. The Takotsubo syndrome patients who have systolic blood pressure less than 100mmHg. 3. The Takotsubo syndrome patients who have severe bradycardia. 4. The Takotsubo syndrome patients who have sepsis. 5. The Takotsubo syndrome patients who did not provide written informed consent.

Design outcomes

Primary

Measure	Time frame
Changes in left ventricular global strain and afterload before and after tVNS	—

Countries

Japan

Contacts

Public ContactMichiaki Nagai

Hiroshima City Asa Hospital Department of Cardiology

nagai10m@r6.dion.ne.jp082-815-5211

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026