The effect of hydroxyzine hydrochloride on intrathecal morphine-induced pruritus for cesarean delivery- A randomized control study

The effect of hydroxyzine hydrochloride on intrathecal morphine-induced pruritus - The effect of hydroxyzine hydrochloride on intrathecal morphine-induced pruritus

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000050981

Enrollment

Registered

2023-05-02

Start date

2021-02-15

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cesarean delivery

Interventions

Intravenous hydroxyzine hydrochloride 25mg right after delivery of the placenta Intravenous 0.9% saline right after delivery of the placenta

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1)Patients did not give consent. 2)Had no time for explanation, (3) used an antihistamine drug, pentazocine before surgery or (4) had an allergy to hydroxyzine, morphine, fentanyl, or bupivacaine. Patients were excluded if they (1) did not give consent, (2) had no time for explanation, (3) used an antihistamine drug, pentazocine before surgery or (4) had an allergy to hydroxyzine, morphine, fentanyl, or bupivacaine.

Exclusion criteria

Exclusion criteria: 1)Extremely emergent cesarean section 2)Patients who have been using an antihistamine drug or pentazocine before surgery 3)Patients who have an allergy to hydroxyzine, morphine, fentanyl, or bupivacaine

Design outcomes

Primary

Measure	Time frame
The severity of pruritus within 24 hours	—

Secondary

Measure	Time frame
Postoperative pain and PONV within 24 hours	—

Countries

Japan

Contacts

Public ContactShuji Uchimura

National Hospital Organization Miyakonojo Medical Center Department of Anesthesiology

syuji_uchimura@med.miyazaki-u.ac.jp0986-23-4111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026