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Association between dose reduction of renin-angiotensin-aldosterone system inhibitors before coronary artery angiography and acute kidney injury: A propensity score-matched study

Association between dose reduction of renin-angiotensin-aldosterone system inhibitors before coronary artery angiography and acute kidney injury: A propensity score-matched study - Association between dose reduction of RAASis before CAG and AKI: A propensity score-matched study

Status
Active, not recruiting
Phases
Unknown
Study type
Unknown
Source
JPRN
Registry ID
JPRN-UMIN000050823
Enrollment
Unknown
Registered
2023-04-13
Start date
2023-04-13
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

inpatients aged 18 or older who were prescribed RAASis for at least one month prior to admission and were undergoing CAG during hospitalization between April 2005 and March 2019. Only first admissions with CAG and those who had a creatinine measurement within 30 days prior to CAG were included in our study. To restrict the focus to patients at risk of AKI, only patients with an estimated glomerular filtration rate (eGFR) of 15-60 ml/min/1.73 m2 were included. To minimize the influence of acute m

Interventions

None listed

Sponsors

Graduate School of Medicine and Public Health, Kyoto University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: inpatients aged 18 or older who were prescribed RAASis for at least one month prior to admission and were undergoing CAG during hospitalization between April 2005 and March 2019. Only first admissions with CAG and those who had a creatinine measurement within 30 days prior to CAG were included in our study. To restrict the focus to patients at risk of AKI, only patients with an estimated glomerular filtration rate (eGFR) of 15-60 ml/min/1.73 m2 were included. To minimize the influence of acute myocardial infarction, unstable angina and the dosage of contrast media, we focused on patients undergoing CAG without percutaneous coronary intervention.

Exclusion criteria

Exclusion criteria: Patients undergoing dialysis within 3 days after admission were excluded. Patients with missing values for the primary diagnosis were also excluded because the primary diagnosis was treated as one of the explanatory variables in a previous study and may influence the incidence of AKI.

Design outcomes

Primary

MeasureTime frame
Acute kidney injury: an absolute increase in serum creatinine of >= 0.3 mg/dl from baseline, which was defined as the last measured serum creatinine level before CAG, within 48 hours or a relative increase in serum creatinine of >= 50% within 7 days—

Secondary

MeasureTime frame
the need for dialysis in-hospital mortality—

Countries

Japan

Contacts

Public ContactHiroyuki Hashimoto

Graduate School of Medicine and Public Health, Kyoto University Department of Pharamacoepidemiology

hashimoto.hiroyuki.36w@st.kyoto-u.ac.jp0757539469

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026