Chronic obstructive pulmonary disease
Conditions
Interventions
To investigate the effect of exercise intervention in COPD patients, we will compare each item between 1) pre-intervention survey, 2) after short-term exercise intervention, and 3) after long-term exe
Sponsors
Gunma University
Jobu Hospital for Respiratory Disease Tone Central Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients 18 years of age or older. 2. Patients who give written consent to participate in this study. 3. Outpatients attending Gunma University Hospital or a collaborating study institution. 4. Patients diagnosed with chronic obstructive pulmonary disease.
Exclusion criteria
Exclusion criteria: 1. Patients who need assistance from others when moving indoors, and who need a walking aid other than a cane or drip stand when walking. 2. Patients who have had a short-term exacerbation within the past 4 weeks of the study entry, according to the GOLD definition. 3. Patients with blood sputum of unknown cause. 4. Patients with angina pectoris, unstable cardiovascular disease, or aortic aneurysm. 5. Patients diagnosed with myocardial infarction or pulmonary embolism 6. Have undergone eye surgery (cataract or glaucoma) within the past 4 weeks from the date of study entry. 7. Underwent thoracic or abdominal surgery within the past 4 weeks from the date of study entry. 8. Those who are unable to give explanation and consent due to cognitive functional aspects or psychiatric symptoms. 9. Those who need anti-inflammatory drugs (oral steroids, NSAIDs, etc.) as treatment. 10. Patients who cannot discontinue active vitamin D3 preparations for the treatment of osteoporosis. 11. Regular use of vitamins, protein drinks, amino acids, or other beverages or supplements in the past month. 12. Patients with chronic kidney disease whose urinalysis shows proteinuria of 0.15 g/gcr or more, or whose eGFR is less than 60 mL/min/1.73 m2, or both have persisted for more than 3 months. Patients with chronic kidney disease or other renal diseases. 13. Patients with a diagnosis of liver dysfunction such as acute hepatitis, chronic hepatitis, fatty liver, cirrhosis, etc. 14. Patients who have regularly exercised for at least 60 minutes every week for at least 3 METs of breathless and sweaty exercise, such as running or water exercise, during the past 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoints of this study will be the difference in blood levels of serum Irisin, and serum 25(OH)D levels at 1) pre-exercise intervention, 2) post-short-term exercise intervention, and 3) post-long-term exercise intervention. Serum Irisin and serum 25(OH)D from the three time periods will be analyzed by two-way ANOVA to confirm the interaction and perform the corresponding multiple comparison tests. A two-sided p-value of 0.05 or less is considered statistically significant in the statistical test. | — |
Secondary
| Measure | Time frame |
|---|---|
| The following items will be compared at 1) pre-exercise intervention, 2) post-short-term exercise intervention, and 3) post-long-term exercise intervention. 1. Pulmonary function test Vital Capacity,Tidal Volume,Expiratory Reverse Volume,Inspiratory Reverse Volume ,Inspiratory Capacity,Forced Vital Capacity (FVC), Forced expiratory volume in 1 second (FEV1),FEV1 as percent of FVC (FEV1/FVC), Maximal Voluntary Ventilation,Peak expiratory flow, FEF25-75%,Maximal expiratory pressure,Maximal expiratory pressure.Pulmonary function test parameters will be expressed as a percentage of actual values and expected values. 2. Blood test data Hematocrit, hemoglobin, erythrocyte count, mean erythrocyte volume, mean erythrocyte hemoglobin volume, mean erythrocyte hemoglobin concentration, red blood cell distribution width, white blood cell count, white blood cell fraction, neutrophil count, eosinophil count, basophil count, monocyte count, lymphocyte count, platelet count. 3. Biochemical test date Total protein, total bilirubin, aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, alkaline phosphatase, gamma glutamyl transpeptidase, cholinesterase, creatine kinase, amylase, uric acid, urea nitrogen, creatinine sodium, potassium, chlor, calcium, blood glucose, total cholesterol, HDL cholesterol, LDL cholesterol, triglyceride, Chyl degree, hemolysis rate, eGFR. 4.Blood Concentration of Serum Myokine Myostatin, BDNF, SPARC, interleukin (IL)-6, IL-7, IL-15, FGF-21, LIF, IGF-1, Fst, Fstl-1, OSM 5. 6-minute walking distance 6. Number of steps per day 7. Brief-type self-administered diet history questionnaire 8. Sun exposure evaluation score | — |
Countries
Japan
Contacts
Public ContactTakeshi Hisada
Gunma University Graduate School of Health Sciences / Department of Respiratory Medicine and Allergy
Outcome results
None listed