Acute coronary syndrome
Conditions
Interventions
After NIRS-IVUS for coronary arteries with FFR >
0.80, NaF-PET/CT of coronary plaque is performed within 1 month. For PET/CT, approximately 200 MBq of 18F-NaF is administered intravenously, and low-dose CT and PET images are taken 60 minutes later o
Sponsors
Aizawa Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients >=18 years of age. 2. Patients with ACS undergoing PCI within 4 weeks before study enrollment. 3. Patients with deferred coronary lesions by FFR (i.e. FFR>0.80) with a moderate stenosis (visual estimation of diameter stenosis >=50%, <90% by coronary angiography) in non-culprit coronary artery, assessed using NIRS-IVUS additionally.
Exclusion criteria
Exclusion criteria: 1. Target vessels* previously treated by PCI. 2. Target vessels* with significant coronary calcification or tortuosity deemed to preclude NIRS-IVUS evaluation. 3. Target vessels* with reference lumen diameter <=2mm. 4. History of CABG. 5. Unstable clinical status (hemodynamic or electrical instability). 6. Patients unwilling or unable to provide informed consent. 7. Life expectancy is less than 1 year at study enrollment. 8. Patients considered unsuitable for the study at the discretion of the operator. *Target vessel is defined as a non-culprit coronary artery with deferred coronary lesions by FFR (i.e. FFR>0.80) with a moderate stenosis (visual estimation of diameter stenosis >=50%, <90% by coronary angiography).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare 18F-sodium fluoride uptake of coronary artery on PET with NIRS-IVUS findings (e.g. maxLCBI(4mm)). | — |
Countries
Japan
Contacts
Public ContactKeisuke Senda
Aizawa Hospital Department of Cardiology
Outcome results
None listed