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Measurement of opioid sensitivity by sympathetic response evoking threshold during sevoflurane anesthesia.

Measurement of opioid sensitivity by sympathetic response evoking threshold during sevoflurane anesthesia. - Measurement of opioid sensitivity by sympathetic response evoking threshold during sevoflurane anesthesia.

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
JPRN
Registry ID
JPRN-UMIN000050700
Enrollment
30
Registered
2023-04-01
Start date
2023-04-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Elective surgery patient over 18 years old

Interventions

None listed

Sponsors

Department of Anesthesiology and Critical Care, Division of Clinical Medical Science, Graduate School of Biomedical Sciences, Hiroshima University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Adult patients who under go open surgery which require invasive blood pressure measurement during remimazolam anesthesia. Patients who are informed enough and presents the will of participation to this study by written form.

Exclusion criteria

Exclusion criteria: Patients with irregular R-R intervals on the electrocardiogram. Patients who cannot measure invasive blood pressure in the radial artery. Patients with severe blood circulation or neuropathy in the upper limbs. Patients with severe stenosis or obstructive lesions of coronary arteries and cerebrovascular disease. Patients with contraindicated use of remifentanil or rocuronium.

Design outcomes

Primary

MeasureTime frame
Correlation coefficient between MECK and ROCBP

Secondary

MeasureTime frame
goodness of fit of the prediction equation for ROCBP by MECK under propofol administration in the previous study to the data of this study

Countries

Japan

Contacts

Public ContactAyaka Ishibashi

Division of Clinical Medical Science, Graduate School of Biomedical Sciences, Hiroshima University Department of Anesthesiology and Critical Care

ayakaishibashi1217@gmail.com81-082-256-5267

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026