Healthy volunteers
Conditions
Interventions
None listed
Sponsors
The University of Tokyo
Tohoku University Hokkaido University Tenshi College Tokyo Medical University Bukkyo University National Institute of Health and Nutrition
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: <Cohort1> 1. Healthy adult volunteers 2. Aged 18 years and over 3. Individuals who have given written consent to participate in the study or who were enrolled in the analysis through an opt-out process <Cohort2> 1. Healthy adult volunteers 2. Aged 18 years and over 3. Individuals who have given written consent to participate in the study or who were enrolled in the analysis through an opt-out process <Cohort3> 1. Healthy volunteers 2. Aged 3-6 years 3. Individuals whose parental consent for the participation was obtained through an opt-out process <Epigenome analysis> 1. Volunteers whose brown adipose tissue has been evaluated by FDG-PET/CT examination 2. Aged 18 years and over 3. Male 4. Individuals who have given written consent to participate in the study or who were enrolled in the analysis through an opt-out process
Exclusion criteria
Exclusion criteria: <Cohort1> 1. Individuals with dysfunction of liver, renal, cardiovascular, respiratory, endocrine and nervous systems, or with metabolic disorders, diabetes, consciousness disorders or other disease. 2. Individuals who regularly take medications for diabetes, hyperlipidemia or hypertension. 3. Individuals who smoke over 21 cigarettes a day or consume alcohol more than 30g a day on average. 4. Individuals who are considered unsuitable for the study by investigators or medical doctor due to other reasons. <Cohort2> 1. Individuals who have the following conditions: glucose intolerance, hyperlipidemia, hypertension, hyperuricemia/gout, coronary artery disease, cerebral infarction, non-alcoholic fatty liver disease, menstrual disorder, sleep apnea syndrome, motor system disease, obesity-related kidney disease or cardiovascular risk. 2. Individuals whose BMI is 30 kg/m2 or more. 3. Individuals with visceral fat area over 100cm2. <Cohort 3> 1. Individuals with acute or chronic diseases or injury <Epigenome analysis> 1. Individuals with dysfunction of liver, renal, cardiovascular, respiratory, endocrine and nervous systems, or with metabolic disorders, diabetes, consciousness disorders or other disease. 2. Individuals who regularly take medications for diabetes, hyperlipidemia or hypertension. 3. Individuals who smoke over 21 cigarettes a day or consume alcohol more than 30g a day on average. 4. Female. 5. Individuals who are considered unsuitable for the study by the principal investigator due to other reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cohort 1:Brown adipose tissue activity by FDG-PET/CT Cohort 2:Brown adipose tissue density by NIR-TRS Cohort 3: Total energy expenditure by the double labeled water (DLW) method | — |
Secondary
| Measure | Time frame |
|---|---|
| Body mass index (BMI), visceral fat area, blood pressure, adaptive thermogenesis, physical activity level, step count, blood glucose level, blood lipid concentration and concentration of other metabolites. | — |
Countries
Japan
Contacts
Public ContactTakeshi Yoneshiro
The University of Tokyo Division of Metabolic Medicine, Research Center for Advanced Science and Technology
Outcome results
None listed